P.Chem 2 Summary Anti-Infectives Incomplete

Anti-infective Agents Joseph Lister (19th Century) introduced antiseptics principles for use in surgery and posttraumatic injury. Paul Ehrlich (1881-1900) a microbiologist, a disciple of Robert Koch, began work with a set of bactericide dyes and antiparasitic organic arsenicals. His goal was to develop compounds that retained antimicrobial effect at the expense of toxicity to the human host. He stag that the dyes and arsenicals could stain tar lower cells selectively and that the antimicrobial properties of the dyes paralleled the maculation activity. This stripping was the first demonstration of selective toxicity, the property of chemicals to pop out ace type of organism while not harming another. Ehrlich uncovering surface the way for the development of the sulfonamides and Penicillins and the elucidation of the mechanisms of their selective toxicity. earlier to Ehrlichs studies, the local antimicrobial properties of Phenol and Iodine were comfortably known, ne vertheless the only useful systemic agents were the herbal remedies of cinchona for Malaria and Ipecac for amoebic dysentery. Ehrlichs discovery of Compound 606, the effective Antisyphilitic dose Salvarsan, was a breakthrough in the treatment of serious, previously untreatable diseases.

1920s where most(prenominal) successful anti-infective agents were based on Group-IIB element Mercury and the Group-VA elements ratsbane and Antimony. Atoxyl (sodium arsanilate and arsphenamine) was utilize for sleeping sickness. Certain dyes such(prenominal) as Gentian purplish and Methylene blue, were in like manner found to be s omewhat effective, as were a a few(prenomin! al) chemicals congeners of the quinine molecule. Heavy metal toxicity after(prenominal) treatment with Mercury, Arsenic, and Antimony disadvantageously limited usefulness of agents containing these elements. 1950 spacious strides were made in anti-infective therapy. The Sulfonamides and Sulfones, more effective Phenolic compounds such as Hexachlorophene, synthetic antimalarial December 4, 2012 compounds, and several...If you want to get a full essay, recite it on our website: OrderCustomPaper.com

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